The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipose Tissue

  • Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intra-abdominal visceral fat.
    (Wang TD, et al. J Clin Endocrinol Metab. 2008 Dec 2. [Epub ahead of print])
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  • Fatty acid binding proteins in adipose tissue: a promising link between metabolic syndrome and atherosclerosis?
    (Krusinová E, et al. Diabetes Res Clin Pract. 2008 Dec 15;82 Suppl 2:S127-34. Epub 2008 Oct 31.)
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Apo / Lipoproteins

  • Metabolic syndrome is strongly associated with chronic subclinical inflammation in patients achieving optimal low-density lipoprotein-cholesterol levels in secondary prevention of cardiovascular disease.
    (Matsuo Y, et al. Circ J. 2008 Dec;72(12):2046-50. Epub 2008 Oct 21.)
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  • Lipid-lowering therapy does not affect the postprandial drop in high density lipoprotein-cholesterol (HDL-c) plasma levels in obese men with metabolic syndrome: a randomized double blind crossover trial.
    (Hajer GR, et al. Clin Endocrinol (Oxf). 2008 Dec;69(6):870-7. Epub 2008 Apr 3.)
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Biomarkers

  • Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome.
    (Gomes VA, et al. Nitric Oxide. 2008 Dec;19(4):345-50. Epub 2008 Sep 5.)
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  • Plasma lecithin: cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness.
    (Dullaart RP, et al. J Clin Endocrinol Metab. 2008 Dec;93(12):4860-6. Epub 2008 Sep 9.)
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Cancer

  • Metabolic syndrome and prostate cancer: A review.
    (Nobes JP, et al. Clin Oncol (R Coll Radiol). 2008 Dec 24. [Epub ahead of print])
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  • Metabolic syndrome and risk of incident diabetes: Findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study.
    (Ford ES, et al. Cardiovasc Diabetol. 2008 Dec 12;7:35.)
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  • Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer.
    (Kintzel PE, et al. Pharmacotherapy. 2008 Dec;28(12):1511-22.)
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  • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis.
    (Paradis V, et al. Hepatology. 2008 Dec 29. [Epub ahead of print])
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Cardiovascular Disease

  • Adipokines and systemic lupus erythematosus: Relationship with metabolic syndrome and cardiovascular disease risk factors.
    (Vadacca M, et al. J Rheumatol. 2008 Dec 15. [Epub ahead of print])
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  • Serum phosphate levels and the risk of cardiovascular disease and metabolic syndrome: a double-edged sword.
    (Park W, et al. Diabetes Res Clin Pract. 2009 Jan;83(1):119-25. Epub 2008 Dec 20.)
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  • Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome. Synergistic effect of inflammation and hyperglycemia.
    (Trřseid M, et al. Diabetes Care. 2008 Dec 17. [Epub ahead of print])
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  • Presence of the metabolic syndrome (MS) is not a better predictor of cardiovascular disease (CVD) than the sum of its components in HIV-infected individuals. Data Collection on Adverse Events of Anti-HIV Drugs (The D:A:D study).
    (Worm SW, et al. Diabetes Care. 2008 Dec 3. [Epub ahead of print])
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  • Putting the Diabetes Prevention Program into Practice: A program for weight loss and cardiovascular risk reduction for patients with metabolic syndrome or type 2 diabetes mellitus.
    (McBride PE, et al. J Nutr Health Aging. 2008 Dec;12(10):745s-9s.)
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  • Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease.
    (Goessling W, et al. Gastroenterology. 2008 Dec;135(6):1935-44, 1944.e1. Epub 2008 Sep 20.)
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  • Illustrating the roles of C-reactive protein in the development of the metabolic syndrome in women--a cross-racial validation.
    (Hwang JJ, et al. Nutr Metab Cardiovasc Dis. 2008 Dec;18(10):671-7. Epub 2008 Apr 1.)
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  • Abnormal cardiac structure and function in the metabolic syndrome: a population-based study.
    (Aijaz B, et al. Mayo Clin Proc. 2008 Dec;83(12):1350-7.)
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Defining the Metabolic Syndrome

  • Comparison of definitions of metabolic syndrome in relation to the risk of developing stroke and coronary heart disease in finnish and swedish cohorts.
    (Qiao Q, et al. Stroke. 2008 Dec 24. [Epub ahead of print])
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  • Metabolic syndrome pathophysiology and clinical presentation.
    (Handelsman Y. Toxicol Pathol. 2008 Dec 19. [Epub ahead of print])
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  • The metabolic syndrome.
    (Cornier MA, et al. Endocr Rev. 2008 Dec;29(7):777-822. Epub 2008 Oct 29.)
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Diabetes

  • The prevalence of chronic diabetic complications and metabolic syndrome is not associated with maternal type 2 diabetes.
    (Scheffel RS, et al. Braz J Med Biol Res. 2008 Dec;41(12):1123-8.)
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  • Effects of lifestyle modification on central artery stiffness in metabolic syndrome subjects with pre-hypertension and/or pre-diabetes.
    (Aizawa K, et al. Diabetes Res Clin Pract. 2008 Dec 19. [Epub ahead of print])
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  • Prevalence of metabolic syndrome among Asian Indian subjects with elevated intermediate glucose response during OGTT.
    (Viswanathan V, et al. Diabetes Res Clin Pract. 2009 Jan;83(1):e17-8. Epub 2008 Dec 5.)
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  • The metabolic syndrome is related to albuminuria in Type 2 diabetes.
    (Bianchi C, et al. Diabet Med. 2008 Dec;25(12):1412-8.)
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  • Lifestyle approach for type 2 diabetes and metabolic syndrome.
    (Esposito K, et al. Curr Atheroscler Rep. 2008 Dec;10(6):523-8. Review.)
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  • Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese.
    (Sun L, et al. J Clin Endocrinol Metab. 2008 Dec;93(12):4690-6. Epub 2008 Sep 16.)
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  • Lipid lowering in the patients with prediabetes/metabolic syndrome: what is the evidence?
    (Steiner G. Curr Opin Lipidol. 2008 Dec;19(6):585-91.)
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  • Laparoscopic treatment of metabolic syndrome in patients with type 2 diabetes mellitus.
    (DePaula AL, et al. Surg Endosc. 2008 Dec;22(12):2670-8. Epub 2008 Mar 18.)
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  • Association among serum perfluoroalkyl chemicals, glucose homeostasis and metabolic syndrome in adolescents and adults.
    (Lin CY, et al. Diabetes Care. 2008 Dec 29. [Epub ahead of print])
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  • Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome.
    (Ahanchi SS, et al. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2388-98. Epub 2008 Oct 17.)
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  • Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of BMI gain during infancy: Data from the New Delhi Birth Cohort.
    (Fall CH, et al. Diabetes Care. 2008 Dec;31(12):2349-56. Epub 2008 Oct 3.)
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Diet, Nutrition & Metabolism

  • Chronic stress, combined with a high-fat/high-sugar diet, shifts sympathetic signaling toward neuropeptide Y and leads to obesity and the metabolic syndrome.
    (Kuo LE, et al. Ann N Y Acad Sci. 2008 Dec;1148:232-7.)
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  • Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet.
    (Volek JS, et al. Lipids. 2008 Dec 12. [Epub ahead of print])
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  • Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced ER stress.
    (Delibegovic M, et al. Diabetes. 2008 Dec 15. [Epub ahead of print])
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  • Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial.
    (Salas-Salvadó J, et al. Arch Intern Med. 2008 Dec 8;168(22):2449-58.)
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  • Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest.
    (Szabo de Edelenyi F, et al. Genes Nutr. 2008 Dec;3(3-4):173-6. Epub 2008 Nov 26.)
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  • Soy protein intake has sex-specific effects on the risk of metabolic syndrome in middle-aged and elderly Chinese.
    (Pan A, et al. J Nutr. 2008 Dec;138(12):2413-21.)
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  • Dairy product consumption and the metabolic syndrome.
    (van Meijl LE, et al. Nutr Res Rev. 2008 Dec;21(2):148-57.)
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  • Associations of serum carotenoid concentrations with the metabolic syndrome: interaction with smoking.
    (Sugiura M, et al. Br J Nutr. 2008 Dec;100(6):1297-306. Epub 2008 Apr 29.)
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  • Red meat intake is associated with metabolic syndrome and plasma C-reactive protein concentrations in women.
    (Azadbakht L, et al. J Nutr. 2008 Dec 11. [Epub ahead of print])
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  • Effects of agycone genistein in a rat experimental model of postmenopausal metabolic syndrome.
    (Bitto A, et al. J Endocrinol. 2008 Dec 9. [Epub ahead of print])
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  • The functional assessment of Alpinia pricei on metabolic syndrome induced by sucrose-containing drinking water in mice.
    (Chou YC, et al. Phytother Res. 2008 Dec 2. [Epub ahead of print])
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  • Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome.
    (Straznicky NE, et al. Am J Clin Nutr. 2009 Jan;89(1):27-36. Epub 2008 Dec 3.)
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  • Preventive effects of nutritional doses of polyphenolic molecules on cardiac fibrosis associated with metabolic syndrome: involvement of osteopontin and oxidative stress.
    (Sutra T, et al. J Agric Food Chem. 2008 Dec 24;56(24):11683-7.)
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  • Fatty acid metabolism: target for metabolic syndrome.
    (Wakil SJ, et al. J Lipid Res. 2008 Dec 1. [Epub ahead of print])
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  • Skin microcirculatory dysfunction is already present in normoglycemic subjects with metabolic syndrome.
    (Kraemer-Aguiar LG, et al. Metabolism. 2008 Dec;57(12):1740-6.)
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Epidemiology

  • Classifying Africans with the metabolic syndrome.
    (Schutte AE, et al. Horm Metab Res. 2008 Dec 22. [Epub ahead of print])
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  • Is socioeconomic position related to the prevalence of metabolic syndrome?: Influence of social class across the life course in a population-based study of older men.
    (Ramsay SE, et al. Diabetes Care. 2008 Dec;31(12):2380-2. Epub 2008 Sep 22.)
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  • Metabolic syndrome: an emerging public health problem in Iranian Women: Isfahan Healthy Heart Program.
    (Sarrafzadegan N, et al. Int J Cardiol. 2008 Dec 17;131(1):90-6. Epub 2008 Jan 10.)
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  • White blood cell count and the metabolic syndrome in older Chinese: the Guangzhou Biobank Cohort Study.
    (Lao XQ, et al. Atherosclerosis. 2008 Dec;201(2):418-24. Epub 2008 Mar 4.)
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  • Prevalence of cardiovascular risk factors and the metabolic syndrome in middle-aged men and women in Gothenburg, Sweden.
    (Welin L, et al. BMC Public Health. 2008 Dec 8;8:403.)
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  • Estradiol and metabolic syndrome in older Italian men: The InCHIANTI study.
    (Maggio M, et al. J Androl. 2008 Dec 4. [Epub ahead of print])
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  • Association between body mass index and core components of metabolic syndrome in 1486 patients with type 1 diabetes mellitus in Japan (JDDM 13).
    (Arai K, et al. Endocr J. 2008 Dec;55(6):1025-32. Epub 2008 Aug 28.)
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  • Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults.
    (Kang YH, et al. Endocr J. 2008 Dec;55(6):1093-102. Epub 2008 Aug 28.)
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  • Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population.
    (Gunji T, et al. Am J Gastroenterol. 2008 Dec;103(12):3005-10.)
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  • Metabolic syndrome in older HIV-infected patients: data from the CORE50 cohort.
    (Adeyemi O, et al. AIDS Patient Care STDS. 2008 Dec;22(12):941-5.)
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Exercise & Physical Activity

  • Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity.
    (Haram PM, et al. Cardiovasc Res. 2008 Dec 18. [Epub ahead of print])
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  • Aerobic exercise and postprandial lipemia in men with the metabolic syndrome.
    (Mestek ML, et al. Med Sci Sports Exerc. 2008 Dec;40(12):2105-11.)
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  • Physical activity and the metabolic syndrome in elderly German men and women: Results from the population based KORA survey.
    (Hahn V, et al. Diabetes Care. 2008 Dec 15. [Epub ahead of print])
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Genetics

  • Developmental delay, dysmorphic features, neonatal spontaneous fractures, wrinkled skin, and hepatic failure: a new metabolic syndrome?
    (Mégarbané A, et al. Am J Med Genet A. 2008 Dec 15;146A(24):3198-201.)
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  • The search for putative unifying genetic factors for components of the metabolic syndrome.
    (Sjögren M, et al. Diabetologia. 2008 Dec;51(12):2242-51. Epub 2008 Oct 14.)
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  • C-Reactive protein, insulin resistance, and metabolic syndrome in a population with a high burden of subclinical infection: insights from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.
    (Howard BV, et al. Diabetes Care. 2008 Dec;31(12):2312-4. Epub 2008 Sep 16.)
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  • Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.
    (Yoshida T, et al. Genomics. 2008 Dec 5. [Epub ahead of print])
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  • GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome.
    (Pi M, et al. PLoS ONE. 2008;3(12):e3858. Epub 2008 Dec 3.)
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Hypertension

  • Hypertension as part of the metabolic syndrome.
    (Cheung B. J Hum Hypertens. 2008 Dec;22(12):871-4. Epub 2008 Jun 12. Review.)
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Obesity

  • Mediators of sympathetic activation in metabolic syndrome obesity.
    (Straznicky NE, et al. Curr Hypertens Rep. 2008 Dec;10(6):440-7.)
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  • Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome.
    (Iwasaki E, et al. J Gastroenterol Hepatol. 2008 Dec;23 Suppl 2:S216-21.)
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Pediatrics

  • Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents.
    (Wamba PC, et al. Eur J Endocrinol. 2008 Dec;159(6):781-90. Epub 2008 Sep 19.)
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  • Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents.
    (Deram S, et al. J Clin Endocrinol Metab. 2008 Dec;93(12):4933-40. Epub 2008 Sep 23.)
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  • Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review.
    (Zimmermann MB, et al. Int J Obes (Lond). 2008 Dec;32 Suppl 6:S11-8.)
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  • Metabolic syndrome by the new IDF criteria in Hong Kong Chinese adolescents and its prediction by using body mass index.
    (Kong AP, et al. Acta Paediatr. 2008 Dec;97(12):1738-42. Epub 2008 Oct 6.)
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  • Prevalence of metabolic syndrome and related characteristics in obese adolescents with and without polycystic ovary syndrome.
    (Rossi B, et al. J Clin Endocrinol Metab. 2008 Dec;93(12):4780-6. Epub 2008 Sep 23.)
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  • Pediatric metabolic syndrome: A growing threat.
    (Celik T, et al. Int J Cardiol. 2008 Dec 19. [Epub ahead of print])
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  • Identifying metabolic syndrome without blood tests in young adults--the Terneuzen Birth Cohort.
    (de Kroon ML, et al. Eur J Public Health. 2008 Dec;18(6):656-60. Epub 2008 Jul 4.)
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  • Prevalence and correlates of the metabolic syndrome in a population-based sample of European youth.
    (Ekelund U, et al. Am J Clin Nutr. 2009 Jan;89(1):90-6. Epub 2008 Dec 3.)
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Psychological Disorders

  • No association of depression and anxiety with the metabolic syndrome: the Norwegian HUNT study.
    (Hildrum B, et al. Acta Psychiatr Scand. 2008 Dec 16. [Epub ahead of print])
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  • Depression: an important comorbidity with metabolic syndrome in a general population.
    (Dunbar JA, et al. Diabetes Care. 2008 Dec;31(12):2368-73. Epub 2008 Oct 3.)
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  • Metabolic syndrome is associated with self-perceived depression.
    (Miettola J, et al. Scand J Prim Health Care. 2008 Dec;26(4):203-10.)
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  • Clinical monitoring and management of the metabolic syndrome in patients receiving atypical antipsychotic medications.
    (Hasnain M, et al. Prim Care Diabetes. 2008 Dec 9. [Epub ahead of print])
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  • Association between metabolic syndrome and depressive symptoms in middle-aged adults: Results from the Whitehall II study.
    (Akbaraly TN, et al. Diabetes Care. 2008 Dec 23. [Epub ahead of print])
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  • The prevalence and predictive value of individual criteria for metabolic syndrome in schizophrenia: A Northern Finland 1966 Birth Cohort Study.
    (Koponen HJ, et al. World J Biol Psychiatry. 2008 Dec 19:1-6. [Epub ahead of print])
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  • Delusion of pregnancy associated with antipsychotic induced metabolic syndrome.
    (Manjunatha N, et al. World J Biol Psychiatry. 2008 Dec 18:1-2. [Epub ahead of print])
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Renal Function

  • The conundrum of hyperuricemia, metabolic syndrome, and renal disease.
    (Nakagawa T, et al. Intern Emerg Med. 2008 Dec;3(4):313-8. Epub 2008 Mar 5.)
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  • The NCEP-ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease.
    (Luk AO, et al. Diabet Med. 2008 Dec;25(12):1419-25.)
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  • Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry.
    (Luk AO, et al. Diabetes Care. 2008 Dec;31(12):2357-61. Epub 2008 Oct 3.)
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  • Are lower urinary tract symptoms influenced by metabolic syndrome?
    (Temml C, et al. Urology. 2008 Dec 30. [Epub ahead of print])
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Risk Factors

  • Having knowledge of metabolic syndrome: does the meaning and consequences of the risk factors influence the life situation of Swedish adults?
    (Frisman GH, et al. Nurs Health Sci. 2008 Dec;10(4):300-5.)
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  • Hyperleptinemia as a robust risk factor of coronary artery disease and metabolic syndrome in type 2 diabetic patients.
    (Kim SK, et al. Endocr J. 2008 Dec;55(6):1085-92. Epub 2008 Aug 23.)
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  • Sociodemographic risk factors associated with metabolic syndrome in a Mediterranean population.
    (Buckland G, et al. Public Health Nutr. 2008 Dec;11(12):1372-8. Epub 2008 Aug 15.)
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  • Does diagnosis of metabolic syndrome predict the likelihood of peripheral arterial disease as defined by a low ankle-brachial index?
    (López-Suárez A, et al. Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):693-697.)
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  • The metabolic syndrome is associated with a higher resistance to intravenous thrombolysis for acute ischemic stroke in women than in men.
    (Arenillas JF, et al. Stroke. 2008 Dec 24. [Epub ahead of print])
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  • Increased serum visfatin in patients with metabolic syndrome and carotid atherosclerosis.
    (Zhong M, et al. Clin Endocrinol (Oxf). 2008 Dec;69(6):878-84. Epub 2008 Mar 20.)
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  • Hierarchical modeling gave plausible estimates of associations between metabolic syndrome and components of antiretroviral therapy.
    (Young J, et al. J Clin Epidemiol. 2008 Dec 22. [Epub ahead of print])
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  • The metabolic syndrome is amplified in hypothyroid rheumatoid arthritis patients: a cross sectional study.
    (Raterman HG, et al. Ann Rheum Dis. 2008 Dec 22. [Epub ahead of print])
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  • Hypogonadotrophic hypogonadism in type 2 diabetes, obesity and the metabolic syndrome.
    (Dandona P, et al. Curr Mol Med. 2008 Dec;8(8):816-28.)
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  • Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome.
    (Chen YJ, et al. Arch Dermatol. 2008 Dec;144(12):1571-5.)
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  • Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross sectional study.
    (Toms TE, et al. Arthritis Res Ther. 2008 Dec 17;10(6):R145. [Epub ahead of print])
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Vascular Biology

  • Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling.
    (González-Navarro H, et al. Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2187-94. Epub 2008 Sep 18.)
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  • Differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome.
    (Maruyama C, et al. J Atheroscler Thromb. 2008 Dec;15(6):306-13. Epub 2008 Dec 6.)
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  • Diagonal earlobe crease are associated with shorter telomere in male Japanese Patients With Metabolic Syndrome.
    (Higuchi Y, et al. Circ J. 2008 Dec 8. [Epub ahead of print])
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  • ApoE knock-out and knock-in mice: atherosclerosis, metabolic syndrome and beyond.
    (Pendse AA, et al. J Lipid Res. 2008 Dec 5. [Epub ahead of print])
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Coordinated by Dr. Scott Grundy, Past-President of the IAS