The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipokines

• The metabolic syndrome Is associated with circulating adipokines in older adults across a wide range of adiposity.
  (You T, et.al. J Gerontol A Biol Sci Med Sci. 2008 Apr;63(4):414-419.)
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Apo / Lipoproteins

• Increased lipoprotein(a) in metabolic syndrome: is it a contributing factor to premature atherosclerosis?
  (Bozbas, et.al. Anadolu Kardiyol Derg. 2008 Apr;8(2):111-5.)
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• Risk stratification of apolipoprotein B, A1, and B/AI ratio on the prevalence of metabolic syndrome: The ATTICA Study.
  (Pitsavos C, et.al. Angiology. 2008 Apr 2. [Epub ahead of print])
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Cardiovascular Disease

• High-normal blood pressure, impaired glucose regulation and metabolic syndrome have variable impact on central artery stiffness.
  (Aizawa K, et.al. Diabetes Res Clin Pract. 2008 Apr 5. [Epub ahead of print])
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• Global coronary heart disease risk assessment of U.S. persons with the metabolic syndrome.
  (Hoang KC, et.al. Diabetes Care. 2008 Apr 4. [Epub ahead of print])
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• The relationship between the metabolic syndrome defined by various criteria and the extent of coronary artery disease.
  (Kasai T, et.al. Atherosclerosis. 2008 Apr;197(2):944-50. Epub 2007 Dec 21.)
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• Carotid arterial stiffness is marginally higher in the metabolic syndrome and markedly higher in type 2 diabetes mellitus in patients with manifestations of arterial disease.
  (Martens FM, et.al. Atherosclerosis. 2008 Apr;197(2):646-53. Epub 2007 Mar 19.)
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• Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study.
  (Saltevo J, et.al. Diabet Med. 2008 Apr 23. [Epub ahead of print])
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Diabetes

• Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal.
  (Accurso A, et.al. Nutr Metab (Lond). 2008 Apr 8;5:9.)
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• Lower wall shear rate of the common carotid artery in treated type 2 diabetes mellitus with metabolic syndrome.
  (Chytilová E, et.al. Physiol Res. 2008 Apr 1. [Epub ahead of print])
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• Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease.
  (Stehouwer CD, et.al. Diabetologia. 2008 Apr;51(4):527-39. Epub 2008 Feb 1.)
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• Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.
  (Wang MY, et.al. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6139-44. Epub 2008 Apr 14.)
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Diet, Nutrition and Metabolism

• Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review.
  (Champagne CM.Nutr Clin Pract. 2008 Apr;23(2):142-51.)
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• Alcohol consumption and metabolic syndrome among Shanghai adults: A randomized multistage stratified cluster sampling investigation.
  (Fan JG, et.al. World J Gastroenterol. 2008 Apr 21;14(15):2418-2424.)
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• Bladder Dysfunction in Rats With Metabolic Syndrome Induced by Long-Term Fructose Feeding.
  (Lee WC, et.al. J Urol. 2008 Apr 21;179(6):2470-2476. [Epub ahead of print])
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• Relation of 25-Hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults.
  (Reis J, et.al. Eur J Endocrinol. 2008 Apr 21. [Epub ahead of print])
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• Associations of serum carotenoid concentrations with the metabolic syndrome: interaction with smoking.
  (Sugiura M, et.al. Br J Nutr. 2008 Apr 29:1-10. [Epub ahead of print])
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Drug Therapy

• Lipid lowering therapy does not affect the postprandial drop in HDL-c plasma levels in obese men with metabolic syndrome.
  (Hajer GR, et.al. Clin Endocrinol (Oxf). 2008 Apr 3. [Epub ahead of print])
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• Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome.
  (Sánchez-Lozada LG, et.al. Am J Physiol Renal Physiol. 2008 Apr;294(4):F710-8. Epub 2008 Jan 23.)
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• Indices of reverse cholesterol transport in subjects with metabolic syndrome after treatment with rosuvastatin.
  (Sviridov D, et.al. Atherosclerosis. 2008 Apr;197(2):732-9. Epub 2007 Aug 20.)
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• TNF-{alpha} antagonism improves vasodilation during hyperinsulinemia in metabolic syndrome.
  (Tesauro M, et.al. Diabetes Care. 2008 Apr 4. [Epub ahead of print])
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Epidemiology

• Waist perimeter cutoff points and prediction of metabolic syndrome risk. A study in a Mexican population.
  (Alonso AL, et.al. Arch Med Res. 2008 Apr;39(3):346-51.)
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• Association among cigarette smoking, metabolic syndrome, and its individual components: the metabolic syndrome study in Taiwan.
  (Chen CC, et.al. Metabolism. 2008 Apr;57(4):544-8.)
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• Metabolic syndrome in three ethnic groups using current definitions.
  (Delisle H, et.al. Appl Physiol Nutr Metab. 2008 Apr;33(2):356-60.)
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• Prevalence of metabolic syndrome and associated risk factors among Turkish adults: Trabzon MetS study.
  (Erem C, et.al. Endocrine. 2008 Apr;33(1):9-20. Epub 2008 Mar 13.)
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• Metabolic syndrome pandemic.
  (Grundy SM.Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):629-36. Epub 2008 Jan 3. Review.)
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• Metabolic syndrome and Framingham risk score for prediction of cardiovascular events in Caribbean Indian patients with blood glucose abnormalities.
  (Jaquet A, et.al. Diabetes Metab. 2008 Apr;34(2):177-81. Epub 2008 Mar 18.)
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• Comparisons of metabolic syndrome definitions in four populations of the Asia-pacific region.
  (Lee CM, et.al. Metab Syndr Relat Disord. 2008 Spring;6(1):37-46.)
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• Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men.
  (Lee GE, et.al. Obesity (Silver Spring). 2008 Apr 3. [Epub ahead of print])
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• Relationship between gamma-glutamyltransferase and metabolic syndrome in a Korean population.
  (Lee MY, et.al. Diabet Med. 2008 Apr;25(4):469-75. Epub 2008 Mar 13.)
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• Validity of the ATP III diagnostic criteria for the metabolic syndrome in an elderly Italian Caucasian population: the Italian Longitudinal Study on Aging.
  (Maggi S, et.al. Atherosclerosis. 2008 Apr;197(2):877-82. Epub 2007 Sep 11.)
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• Serum uric acid and components of the metabolic syndrome in non-diabetic populations in Mauritian Indians and creoles and in Chinese in Qingdao, China.
  (Nan H, et.al. Metab Syndr Relat Disord. 2008 Spring;6(1):47-57.)
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• Comparison of serum uric acid levels between Japanese with and without metabolic syndrome.
  (Numata T, et.al. Diabetes Res Clin Pract. 2008 Apr;80(1):e1-5. Epub 2008 Mar 7.)
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• Prevalence of metabolic syndrome and serum marker levels in patients with four subtypes of cerebral infarction in Japan.
  (Yokokawa H, et.al. J Clin Neurosci. 2008 Apr 12. [Epub ahead of print])
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Exercise

• Short-term training effects on diastolic function in obese persons with the metabolic syndrome.
  (Baynard T, et.al. Obesity (Silver Spring). 2008 Apr 3. [Epub ahead of print])
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• The effect of metabolic syndrome components on exercise performance in patients with intermittent claudication.
  (Gardner AW, et.al. J Vasc Surg. 2008 Apr 11. [Epub ahead of print])
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• Relationship between the metabolic syndrome and physical activity energy expenditure: a MONET study.
  (Karelis AD, et.al. Appl Physiol Nutr Metab. 2008 Apr;33(2):309-14.)
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• Metabolic syndrome status changes with fitness level change: a retrospective analysis.
  (Maxwell MS, et.al. Metab Syndr Relat Disord. 2008 Spring;6(1):8-14.)
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• A preliminary study of the effects of Tai Chi and Qigong medical exercise on indicators of metabolic syndrome and glycaemic control in adults with elevated blood glucose.
  (Xin L, et.al. Br J Sports Med. 2008 Apr 2. [Epub ahead of print])
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Genetics

• Association of peroxisome proliferator-activated receptorgamma gene Pro12Ala and C161T polymorphisms with metabolic syndrome.
  (Dongxia L, et.al. Circ J. 2008 Apr;72(4):551-7.)
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• Genome-wide linkage scan for the metabolic syndrome: The GENNID Study.
  (Edwards KL, et.al. Obesity (Silver Spring). 2008 Apr 17. [Epub ahead of print])
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• Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat.
  (Gilibert S, et.al. Physiol Genomics. 2008 Apr 22;33(2):212-7. Epub 2008 Feb 19.)
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• Genetics of metabolic syndrome.
  (Joy T, et.al. Curr Diab Rep. 2008 Apr;8(2):141-8.)
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• Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome.
  (Mager U, et.al. Eur J Endocrinol. 2008 Apr;158(4):499-510.)
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• Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The Women's Genome Health Study.
  (Ridker PM, et.al. Am J Hum Genet. 2008 Apr 23. [Epub ahead of print])
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• Genetic polymorphisms of beta2- and beta3-adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women.
  (Rooyen JM, et.al. Exp Clin Endocrinol Diabetes. 2008 Apr;116(4):236-40.)
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• The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome.
  (Sandhofer A, et.al. Obesity (Silver Spring). 2008 Apr;16(4):919-22. Epub 2008 Jan 24.)
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• Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.
  (Scott EM, et.al. Int J Obes (Lond). 2008 Apr;32(4):658-62. Epub 2007 Dec 11.)
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• Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study.
  (Stirnadel H, et.al. Atherosclerosis. 2008 Apr;197(2):868-76. Epub 2007 Sep 21.)
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• Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease.
  (Wiltshire S, et.al. Hum Genet. 2008 Apr;123(3):307-13. Epub 2008 Feb 21.)
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• Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men.
  (Zhang L, et.al. Metabolism. 2008 Apr;57(4):502-5.)
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Hypertension

• Aldosterone in salt-sensitive hypertension and metabolic syndrome.
  (Fujita T.J Mol Med. 2008 Apr 25. [Epub ahead of print])
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• Evidence for no global effect of metabolic syndrome per se on early hypertensive sequelae.
  (Tsioufis C, et.al. J Hypertens. 2008 Apr;26(4):773-9.)
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• The underlying mechanisms for development of hypertension in the metabolic syndrome.
  (Yanai H, et.al. Nutr J. 2008 Apr 17;7:10.)
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Innovative Techniques / Modeling

• Impaired capsaicin-induced relaxation of coronary arteries In a porcine model of the metabolic syndrome.
  (Bratz IN, et.al. Am J Physiol Heart Circ Physiol. 2008 Apr 4. [Epub ahead of print])
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Lifestyle Interventions / Treatment

• Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study.
  (Ilanne-Parikka P, et.al. Diabetes Care. 2008 Apr;31(4):805-7. Epub 2008 Jan 9.)
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• Metabolic syndrome in railway employees and its relation to lifestyle factors.
  (Parale GP, et.al. Metab Syndr Relat Disord. 2008 Spring;6(1):58-63.)
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Metabolic Syndrome in Women

• Metabolic syndrome in normal and complicated pregnancies.
  (Bartha JL, et.al. Eur J Obstet Gynecol Reprod Biol. 2008 Apr;137(2):178-84. Epub 2007 Aug 6.)
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• Menopause, the metabolic syndrome, and mind-body therapies.
  (Innes KE, et.al. Menopause. 2008 Apr 17. [Epub ahead of print])
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• Metabolic syndrome after menopause and the role of hormones.
  (Lobo RA.Maturitas. 2008 Apr 11. [Epub ahead of print])
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• The prevalence of metabolic syndrome among US women of childbearing age.
  (Ramos RG, et.al. Am J Public Health. 2008 Apr 29. [Epub ahead of print])
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• Revised optimal cut-off point of waist circumference for the diagnosis of metabolic syndrome in Japanese women and the influence of height.
  (Shimajiri T, et.al. J Atheroscler Thromb. 2008 Apr 3. [Epub ahead of print])
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Non-Alcholic Fatty Liver Disease

• Nonalcoholic steatohepatitis and the metabolic syndrome.
  (Jiang J, et.al. Metab Syndr Relat Disord. 2008 Spring;6(1):1-7.)
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• Liver stiffness values in apparently healthy subjects: Influence of gender and metabolic syndrome.
  (Roulot D, et.al. J Hepatol. 2008 Apr;48(4):606-613. Epub 2008 Jan 3.)
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Obesity

• Intra-abdominal fat and metabolic syndrome are associated with larger infrarenal aortic diameters in patients with clinically evident arterial disease.
  (Gorter PM, et.al. J Vasc Surg. 2008 Apr 25. [Epub ahead of print])
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• Adrenocortical dysfunction in obesity and the metabolic syndrome.
  (Krug AW, et.al. Horm Metab Res. 2008 Apr 30. [Epub ahead of print])
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• Metabolic syndrome after laparoscopic bariatric surgery.
  (Nugent C, et.al. Obes Surg. 2008 Apr 9. [Epub ahead of print])
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• Coronary collaterals in obese patients: Impact of metabolic syndrome.
  (Sasmaz H, et.al. Angiology. 2008 Apr 29. [Epub ahead of print])
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• Bariatric surgery outcomes in morbidly obese with the metabolic syndrome at US academic centers.
  (Varela JE, et.al. Obes Surg. 2008 Apr 22. [Epub ahead of print])
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• Insulin, hs-CRP, leptin, and adiponectin. An analysis of their relationship to the metabolic syndrome in an obese population with an elevated waist circumference.
  (Yan E, et.al. Metab Syndr Relat Disord. 2008 Spring;6(1):64-73.)
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Pediatrics

• Childhood obesity, hypertension, the metabolic syndrome and adult cardiovascular disease.
  (Beilin L, et.al. Clin Exp Pharmacol Physiol. 2008 Apr;35(4):409-11.)
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• Body mass index status is effective in identifying metabolic syndrome components and insulin resistance in Pacific Island teenagers living in New Zealand.
  (Grant AM, et.al. Metabolism. 2008 Apr;57(4):511-6.)
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• Adolescents with metabolic syndrome have a history of low aerobic fitness and physical activity levels.
  (McMurray RG, et.al. Dyn Med. 2008 Apr 4;7:5.)
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• Physical activity, metabolic syndrome, and overweight in rural youth.
  (Moore JB, et.al. J Rural Health. 2008 Spring;24(2):136-42.)
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• Association between the metabolic syndrome and serum cortisol in overweight Latino youth.
  (Weigensberg MJ, et.al. J Clin Endocrinol Metab. 2008 Apr;93(4):1372-8. Epub 2008 Feb 5.)
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Psychiatric Disorders

• Typical and atypical antipsychotics differentially affect long-term incidence rates of the metabolic syndrome in first-episode patients with schizophrenia: A retrospective chart review.
  (De Hert M, et.al. Schizophr Res. 2008 Apr;101(1-3):295-303. Epub 2008 Mar 4.)
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• Metabolic syndrome and psychosocial deprivation. Data collected from a Paris suburb.
  (La Rosa E, et.al. Diabetes Metab. 2008 Apr;34(2):155-161. Epub 2008 Apr 10.)
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• Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: Prospective data from phase 1.
  (Meyer JM, et.al. Schizophr Res. 2008 Apr;101(1-3):273-86. Epub 2008 Feb 6.)
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• Metabolic syndrome in first episode schizophrenia - A randomized double-blind controlled, short-term prospective study.
  (Saddichha S, et.al. Schizophr Res. 2008 Apr;101(1-3):266-72. Epub 2008 Feb 11.)
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Risk Factors

• Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 health check-up Koreans.
  (Chung SJ, et.al. Gut. 2008 Apr 25. [Epub ahead of print])
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• Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: A controlled, population-based study (HUNT-2).
  (Dørum A, et.al. Gynecol Oncol. 2008 Apr 11. [Epub ahead of print])
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• Visceral adipose tissue specific persistence of Mycobacterium tuberculosis may be reason for the metabolic syndrome.
  (Erol A.Med Hypotheses. 2008 Apr 28. [Epub ahead of print])
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• Metabolic syndrome Is not a risk factor for kidney dysfunction in obese non-diabetic subjects.
  (Gatti A, et.al. Obesity (Silver Spring). 2008 Apr;16(4):899-901. Epub 2008 Jan 31.)
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• Influence of age on the association of retinol-binding protein 4 with metabolic syndrome.
  (Gavi S, et.al. Obesity (Silver Spring). 2008 Apr;16(4):893-5. Epub 2008 Jan 31.)
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• Metabolic syndrome: a major risk factor for atherosclerosis in HIV-infected patients (SHIVA study).
  (Martin Lde S, et.al. Presse Med. 2008 Apr;37(4 Pt 1):579-84. Epub 2008 Feb 29.)
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• Tumor necrosis factor-alpha is a marker of familial combined hyperlipidemia, independently of metabolic syndrome.
  (Pauciullo P, et.al. Metabolism. 2008 Apr;57(4):563-8.)
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• Hyperuricaemia is an independent factor for the metabolic syndrome in a sub-Saharan African population: a factor analysis.
  (Reimann M, et.al. Atherosclerosis. 2008 Apr;197(2):638-45. Epub 2007 Oct 22.)
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• Eating meals irregularly: A novel environmental risk factor for the metabolic syndrome.
  (Sierra-Johnson J, et.al. Obesity (Silver Spring). 2008 Apr 3. [Epub ahead of print])
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• Prevalence and factors associated with metabolic syndrome in patients with rheumatoid arthritis and systemic lupus erythematosus.
  (Zonana-Nacach A, et.al. J Clin Rheumatol. 2008 Apr;14(2):74-7.)
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Screening & Diagnosis

• A stepwise approach to assess the impact of clustering cardiometabolic risk factors on carotid intima-media thickness: the metabolic syndrome no-more-than-additive.
  (Fadini GP, et.al. Eur J Cardiovasc Prev Rehabil. 2008 Apr;15(2):190-6.)
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• Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease.
  (Gorter PM, et.al. Atherosclerosis. 2008 Apr;197(2):896-903. Epub 2007 Sep 19.)
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• Self-reported prevalence and awareness of metabolic syndrome: findings from SHIELD.
  (Lewis SJ, et.al. Int J Clin Pract. 2008 Apr 29. [Epub ahead of print])
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Sleep Disorders

• Relationship between metabolic syndrome and sleep-disordered breathing in patients with cardiovascular disease--metabolic syndrome as a strong factor of nocturnal desaturation.
  (Takama N, et.al. Intern Med. 2008;47(8):709-15. Epub 2008 Apr 16.)
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Stroke

• The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland.
  (Wang J, et.al. Stroke. 2008 Apr;39(4):1078-83. Epub 2008 Mar 6.)
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Vascular Biology

• Relationship between plasma resistin concentrations, inflammatory chemokines, and components of the metabolic syndrome in adults.
  (Aquilante CL, et.al. Metabolism. 2008 Apr;57(4):494-501.)
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• Relation of the metabolic syndrome to quantity of coronary atherosclerotic plaque.
  (Butler J, et.al. Am J Cardiol. 2008 Apr 15;101(8):1127-30. Epub 2008 Feb 11.)
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• Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome.
  (Popeijus HE, et.al. Int J Obes (Lond). 2008 Apr 22. [Epub ahead of print])
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• Prevalence of metabolic syndrome in patients with clinically advanced peripheral vascular disease.
  (Qadan LR, et.al. Angiology. 2008 Apr-May;59(2):198-202. Epub 2008 Apr 2.)
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• Assessment of aortic pulse wave velocity and cardiac diastolic function in subjects with and without the metabolic syndrome.
  (D Roes S, et.al. Diabetes Care. 2008 Apr 8. [Epub ahead of print])
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• Patients with metabolic syndrome exhibit higher platelet activity than those with conventional risk factors for vascular disease.
  (Serebruany VL, et.al. J Thromb Thrombolysis. 2008 Apr;25(2):207-213. Epub 2007 May 26.)
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• Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome.
  (Vural B, et.al. Cardiovasc Pathol. 2008 Apr 14. [Epub ahead of print])
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