Triglycerides-to-high-density lipoprotein cholesterol ratio as strong predictor of first coronary event
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In this study, the predictive value of a surrogate marker of insulin resistance, the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C), for the incidence of a first coronary event in working men was investigated. To this end, a sample of 208 case subjects with myocardial infarction, unstable angina pectoris, or subclinical myocardial ischaemia detected through electrocardiographic abnormalities was compared with 2080 control subjects, both groups being well-matched as regards general patient’s characteristics. In case subjects, the TG/HDL-C ratio was significantly higher than in controls. Smoking-adjusted multivariable analysis revealed that TG/HDL-C increased by 50% the risk of a first coronary event, whereas low-density lipoprotein cholesterol levels were indicative of a more moderate increased risk. The predictive value of metabolic syndrome and hypertension did not reach statistical significance. Furthermore, the TG/HDL-C ratio was associated with a first coronary event in all categories of body mass indices (BMI). Thus, the TG/HDL-C ratio appears to be a strong predictor for a first coronary event regardless of BMI.
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