Metabolic syndrome associated with impaired left ventricular synchronicity
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To assess left ventricular (LV) diastolic and systolic synchronicity, tissue Doppler echocardiography was performed in 135 subjects with metabolic syndrome and in 100 controls. Diastolic and systolic synchronicity was determined by measuring the SD of time-to-peak myocardial early diastolic relaxation and systolic contraction and the maximal difference in time-to-peak myocardial early diastolic relaxation and systolic contraction with six basal and six middle LV segments. When compared to controls, patients with metabolic syndrome exhibited significantly prolonged SD of time-to-peak myocardial early diastolic relaxation and SD of time-to-peak myocardial early systolic contraction, prolonged maximal difference in time-to-peak myocardial early diastolic relaxation and maximal difference in time-to-peak myocardial early systolic contraction among the 12 left ventricular segments. Independent predictors of impaired diastolic synchronicity in metabolic syndrome included waist-to-hip ratio, fasting blood glucose, age and LV mass for height to the power 2.7, while age and LV mass for height to the power 2.7 were independent predictors of impaired systolic synchronicity. Thus, patients with metabolic syndrome present with impaired LV diastolic and systolic synchronicity.
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