Reduced forced vital capacity associated with incremental mortality in metabolic syndrome patients
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The study was designed to investigate whether reduced pulmonary function was associated with increased mortality in subjects presenting with metabolic syndrome or diabetes, two conditions associated with reduced pulmonary function. To this end, 5633 US adults from the Third National Health and Nutrition Examination Survey, who had never smoked and were free from cardiovascular or obstructive lung disease, were studied. Cox regression analysis revealed that age- and sex-adjusted mortality rates increased in a stepwise manner as predicted forced vital capacity (FVC) decreased in patients with or without diabetes. Patients with low FVC had a fourfold increase in mortality among subjects with metabolic syndrome and more than a twofold increase among those with neither metabolic syndrome nor diabetes mellitus, when compared to patients with high FVC. However, in patients with diabetes mellitus, FVC did not contribute further to mortality risk. These results suggest that lung function evaluation might be useful for risk stratification in subjects presenting with metabolic syndrome.
Abstract
