The TG/HDL-C ratio as a powerful independent predictor of all-cause mortality and cardiovascular events
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The study aimed to investigate the prognostic utility among high-risk women of the triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, a marker for both insulin resistance and/or atherogenic dyslipidaemia. To this end, a total of 544 women without prior myocardial infarction or coronary revascularization, referred for clinically-indicated coronary angiography, were studied. Multivariate Cox-proportional hazards models for all-cause mortality and cardiovascular events were constructed using log(TG/HDL-C) as predictor variable, accounting for traditional cardiovascular risk factors. Over a median follow-up period of 6 years, death and cardiovascular events increased across TG/HDL-C quartiles. In models adjusting for other cardiovascular risk factors (e.g. age, smoking, hypertension, diabetes and angiographic coronary disease severity), the TG/HDL-C ratio was a strong independent predictor of all-cause mortality. After adjusting for demographic and clinical variables, the multivariate hazard ratio for cardiovascular events was 1.54, which became non-significant when angiographic results were taken into account, suggesting that part of the risk associated with high TG/HDL-C may covariate alongside coronary artery disease severity. In conclusion, the TG/HDL-C ratio appears to be a powerful independent predictor of all-cause mortality and cardiovascular events in women with suspected ischaemia.
Abstract
