Higher plasma HDL cholesterol levels associated with lower risk of incident chronic kidney disease in type 2 diabetic adults
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Hypo-HDL-cholesterolaemia predicts incident microalbuminuria, an end-organ marker for early renovascular damage. This prospective study including 1987 patients with type 2 diabetes, with normal or near-normal kidney function at baseline, aimed to prospectively assess the effect of plasma HDL cholesterol levels on the incidence of chronic kidney disease (CKD). During a median 5-year follow-up, 11.8% of patients developed incident CKD defined as glomerular filtration rate ≤60 mL/min/1.73 m2. Multivariate regression analysis revealed that higher HDL cholesterol levels were independently associated with lower risk of CKD after adjusting for numerous confounding factors (including age, body mass index, hypertension, smoking, diabetes duration and control, retinopathy, albuminuria, and anti-hypertensive drug use). Higher plasma levels of HDL cholesterol thus appear to be associated with a lower risk of incident CKD in a large cohort of adult subjects presenting with type 2 diabetes.
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