Excess adiposity shown to be strongly related to first non-ST-segment elevation myocardial infarction
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Excess adiposity is known as a major determinant of dysadipokinaemia and systemic inflammatory factors as well as with higher prevalence of conventional risk factors, all associated with coronary plaque rupture risk. The study was conducted to test the hypothesis that obesity was associated with occurrence of myocardial infarction at earlier ages. To this end, data from 111,847 patients with non-ST-segment elevation myocardial infarction (NSTEMI) included in the CRUSADE registry were retrospectively analysed. A strong, inverse linear relationship was found between BMI and earlier age of occurrence of inaugural NSTEMI. The mean patient age at the time of first NSTEMI was 74.6 years for the leanest BMI cohort compared with 58.7 years for the most obese cohort, the difference being highly significant. In conclusion, the study results demonstrate that excess adiposity is strongly related to first NSTEMI occurring prematurely.
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