Independent association of insulin and 24-h urinary noradrenaline with metabolic syndrome
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This study, including 651 euthyroid overweight or obese patients, aimed to investigate whether metabolic syndrome (ATP III criteria) was associated with insulin, catecholamines, and thyroid hormones levels, independently of age and gender. Insulin resistance was estimated by homeostasis model assessment for insulin resistance (HOMA-IR). Compared with subjects without metabolic syndrome, those with metabolic syndrome exhibited significantly higher insulin and free tri-iodothyronine (FT3) serum levels and significantly higher 24-hour urinary noradrenaline. Among these patients, there was a direct association between the number of metabolic syndrome defining-components and insulin and FT3 serum levels, and 24-h urinary noradrenaline as well. Multiple regression analysis revealed that metabolic syndrome was independently associated with age, male gender, insulin and 24-h urinary noradrenaline. Insulin and noradrenaline may contribute independently to the pathogenesis of the metabolic syndrome.
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