Metabolic syndrome shown to play a crucial role in the development of recurrent ischaemic stroke
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The aim of this one-year hospital-based study conducted in Taiwan was to compare the stroke subtype distribution and risk factor profiles between recurrent ischaemic stroke (RIS) and first-ever stroke (FES). Insufficient control of conventional risk factors and of dyslipidaemia is increasingly recognized as contributor to stroke recurrence. In total, 587 FES and 475 RIS enrolled study participants were categorized into four stroke subtypes according to a modified TOAST stroke subtype classification system. Multivariate regression analysis identified hypertension, diabetes mellitus, low HDL cholesterol and older age as significant RIS risk factors, with the former three RIS factors being further linked with the large-vessel subtype. In the RIS group, including its large-vessel subtype, metabolic syndrome was significantly more common. Progressively increasing odds ratios from 1.49 to 2.02 with increasing number of metabolic syndrome components were observed for recurrent large-vessel ischaemic stroke. Metabolic syndrome appears to play a crucial role in the development of RIS in the Taiwanese population, including large-vessel infarction.
Abstract
