Abdominal visceral fat compartment as a unique, pathogenic fat depot

To assess the incremental utility of measuring both subcutaneous abdominal adipose tissue (SAT) and visceral adipose tissue (VAT) in association with metabolic risk factors and underlying heredity in a population-based cohort, 3001 participants from the Framingham Heart Study underwent multidetector computed tomography assessment of SAT and VAT volumes, between 2002 and 2005, and metabolic significantly associated with blood pressure, fasting plasma glucose, triglycerides, and high-density lipoprotein cholesterol and with increased odds of hypertension, impaired fasting glucose, diabetes, and metabolic syndrome (P range <0.01). However, VAT was more strongly associated with an adverse metabolic profile even after accounting for standard anthropometric indexes. Heritability values for SAT and VAT were 57% and 36%, respectively. In conclusion, specific measurement of VAT may provide a more comprehensive assessment of metabolic risk associated with variation in fat distribution/expansion. risk factors were examined in relation to increments of SAT and VAT. Among both sexes, SAT and VAT were

Keywords:
Blood pressure – BMI –Diabetes – HDL-cholesterol – Hypertension – Impaired fasting glucose – Metabolic syndrome – Plasma glucose – Subcutaneous adipose tissue – Triglycerides – Visceral adipose tissue – Waist circumference