Independent inter-relationships between C-reactive protein, metabolic syndrome and chronic kidney diseasen

The study was aimed to investigate the inter-relationships between C-reactive protein (CRP), metabolic syndrome (ATP III criteria) and chronic kidney disease (CKD) defined as a glomerular filtration rate <60 mL/min/1.73 m2 and/or microalbuminuria. Among the 9586 subjects without diabetes and hypertension (the latter being risk factors for CKD) included in the study, the prevalence of CKD was 6.2% among subjects without metabolic syndrome and 13.1% among those with metabolic syndrome (P<0.001). Multivariate model analysis revealed that high blood pressure, high fasting glucose, abdominal obesity, and high CRP (cutpoint 3 mg/L) were independently associated with prevalent CKD. The multivariate adjusted odds for CKD were 1.48 for high CRP/without metabolic syndrome and 1.90 for low CRP/with metabolic syndrome as compared with low CRP/without metabolic syndrome. Moreover, subjects with high CRP and metabolic syndrome had a 3.26-fold greater odds of having CKD. Therefore, metabolic syndrome and high CRP appear to be independently associated with increased prevalence of CKD in nondiabetic nonhypertensive subjects.

Abstract

Keywords:
Abdominal obesity – Plasma glucose – CRP – High blood pressure – Inflammation – Kidney disease – NCEP ATP III definition