Possible link between severe generalized periodontitis, systemic inflammation and a dysmetabolic state
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The study was designed to investigate the association between severe periodontitis (a chronic and progressive gingival inflammatory process associated with bacterial dental plaque) and increase in inflammatory and metabolic risk factors for cardiovascular disease. To this end, blood samples were collected in 302 patients with severe periodontitis and 183 healthy controls, and differences in systemic inflammatory (leukocyte numbers and differential counts) and metabolic markers (lipids and glucose) were assessed. Compared with controls, periodontitis subjects exhibited a low-grade systemic inflammation, dyslipidaemia as defined by lower HDL-cholesterol and higher LDL-cholesterol, and increased non-fasting serum glucose levels. Furthermore, there was trend for a dose dependent effect of the number of periodontal pockets on the tested inflammatory and metabolic markers, suggesting a possible link between severe generalized periodontitis, systemic low-grade inflammation and a dysmetabolic state.
Abstract
