Low adiponectin levels, but not resistin, as significant risk factor for the development of cardiovascular events in Korean patients with type 2 diabetes

Adiponectin and resistin have been shown to significantly affect insulin resistance and atherosclerosis. A prospective study, designed to assess the role of adiponectin and resistin at baseline (2001) as predictors of cardiovascular events considered as hard endpoints, was conducted in 343 unrelated Korean patients with type 2 diabetes. The primary endpoint was defined as one of cardiovascular death, myocardial infarct, CABG, stroke, unstable angina or overt nephropathy. During the 42-month follow-up period, 38 patients (11.1%) experienced primary endpoint. After adjustment for age, sex, BMI, blood pressure and lipid status, participants in the lowest quartile of adiponectin levels had significantly (P=0.034) increased risk of primary endpoint as compared with those in the highest quartile. By contrast, resistin levels had no influence on the risk of primary endpoint.

Abstract